FREE · ACMG & AMP ALIGNED

The variant, classified
Evidence and all

A free, searchable pathogenicity resource for germline (rare disease) and somatic (cancer) variants SNVs, indels and SVs, each with a transparent ACMG/AMP evidence trail. Try one on the right.

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5,000+ rare conditions 26 cancer types 0.96 CNV AUC
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Examples
Chr
Pos
Ref
Alt
Type
Gene
Zyg
CADD (PP3)
Pathogenicity:
:
:
:
Pharmacogenomic (SeqRx)
Gene
Drug
RxNorm
Open full report on variant.genomearc.com
One resource · Two domains

Germline and somatic, side by side

Germline · ACMG

Rare & inherited disease

ACMG-aligned classification against ClinVar and GenomeArc's proprietary clinical databases, spanning hereditary cancers.

  • 5,000+ rare conditions with inheritance annotation
  • Pathogenic / likely-pathogenic / VUS with evidence codes
  • Validated germline CNV accuracy of AUC 0.96
Somatic · AMP

Cancer & oncogenicity

AMP-guideline oncogenicity assessment pinpointing Tier 1A variants linked to FDA-approved drugs, with variant-level pharmacogenomics.

  • AMP tier insights across 26 major cancers
  • Tier 1A/B → FDA-approved therapy linkage
  • Variant-level pharmacogenomic annotation
Transparent by design

Every call shows its work

01

Search the variant

Gene, HGVS, genomic coordinate or rsID SNVs, indels and long-read SVs.

02

Evidence is mapped

Evaluated against ACMG or AMP criteria and cross-checked with curated databases.

03

Read the classification

A traceable call with every contributing evidence code, ready for reporting.

Enterprise

Premium Horizon™ whole genomes in under 15 minutes

Cloud or on-prem tertiary analysis of 5M+ SNV/indels and SVs, with somatic AMP tiers, TMB, mutation signatures, clonal trees, embedded AI agents, and multi-OMICs single-cell insight.

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Free

Search any variant
in seconds

Open variant.genomearc.com