Horizon Intelligence

Ask the genome
Get the answer

Purpose-built AI agents live inside the multimodal platform turning natural-language questions into cited, ACMG-graded variant answers in under a second.

horizon.genomearc.com / intelligence live
Intelligence Prompt
PhenoGene VariantSearch
waiting for prompt…
Inside the platform

Three agents
One conversation

Horizon Intelligence isn't a single model it's a coordinated set of purpose-built agents, each fluent in a different part of the genomic workflow.

PhenoGene Agent
PhenoGene Agent
From unstructured phenotypic notes to a biologically meaningful gene panel.

PhenoGene integrates unstructured clinical text with a patient's genome to build phenotypically meaningful gene panels, especially valuable for complex cases with unresolved genomic diagnoses.

Free text into HPO
Patient-specific panels
Rare & unresolved cases
Horizon Agent
Horizon Agent
The multi-agent core embedded across the platform.

GenomeArc believes AI can fundamentally accelerate genomics. Horizon is a purpose-built agent inside the multimodal platform, coordinating specialist agents so users can manipulate data and surface deeper insight without ever leaving their workflow.

Multi-agent routing
Context-aware memory
Grounded in your data
Intelligence Prompt
Intelligence Prompt
Natural language for variant search.

Ask in plain language; the platform searches pathogenic variants for a gene or variant. The prompt is trained on genomic knowledge and uses the platform's own samples inside its search queries.

Natural language input
Grounded in cohort data
Cited variant results
Capabilities

An intelligence engine, not a chatbot

Conversational context

Refine a case across turns; the agent keeps the context and evidence stack.

Natural-language search

Ask for variants by gene, phenotype, or population grounded in your own cohorts.

Knowledge graph

Genes, phenotypes, pathways and disease connected powering phenogene matching.

Cross-modality

SNVs, indels, CNVs, SVs, RNA and proteome evidence assessed together.

Automated interpretation

Draft classifications proposed with ACMG/AMP evidence pre-attached.

Grounded, not generic

Every response tied to curated sources; nothing is hallucinated.

Bring one case. Leave with an answer

We'll walk a real case through Horizon Intelligence end to end, in
a single session.